New Alzheimer's Treatment Administered Here
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New Therapies for Alzheimer's and Mild Cognitive Impairment
The Therapeutic Goods Administration (TGA) has approved donanemab (brand name Kisunla) for the treatment of people with Mild Cognitive Impairment (MCI) or early Alzheimer’s disease.
Patient eligibility
To be considered for treatment, patients must meet all of the following criteria:
- Evidence of a “rapid forgetting” pattern of memory impairment, or an isolated cognitive syndrome caused by Alzheimer’s disease (for example, primary progressive aphasia or posterior cortical atrophy)
- A diagnosis of mild cognitive impairment or mild dementia due to Alzheimer’s disease
- Minimal impairment in daily functioning
- A Mini-Mental State Examination (MMSE) score between 20 and 28
- Confirmed amyloid pathology in the brain, demonstrated by:
- cerebrospinal fluid testing via lumbar puncture, or
- amyloid brain imaging
- Completion of genetic testing for ApoE4
- Patients with two copies of the ApoE4 gene are not suitable candidates for Kisunla
Funding and rebates
The medication and associated investigations are not subsidised by:
- the Pharmaceutical Benefits Scheme (PBS)
- Medicare
- private health insurance
All costs are therefore out-of-pocket.
Important information for patients and families
It is essential that patients and their families understand the following:
- Donanemab slows the progression of Alzheimer’s disease but does not stop or reverse the condition
- Treatment should be combined with other evidence-based approaches, including physical exercise, cognitive stimulation, and broader brain-health strategies
- Common side effects include mild infusion-related reactions, which may be uncomfortable but are usually short-lived
- Less common but serious risks include brain swelling (ARIA-E) and brain bleeding (ARIA-H)
- These complications may require treatment and can result in temporary or permanent cognitive decline, disability, or, in rare cases, death
- Regular MRI scans are required to monitor for these risks
- Patients should seek urgent medical assessment if concerning symptoms arise between scheduled scans
Costs to consider
Before commencing treatment, patients should carefully consider the financial implications, which typically include:
- ApoE genetic testing: approximately $200
- Donanemab (Kisunla): estimated at $4,700 per infusion
- Approximately $56,400 per year + GST
- Infusion administration costs: approximately $600 per session, typically over 18 months
- Amyloid PET scans: approximately $2,500 per scan, usually performed every six months to assess treatment response and determine whether therapy can be ceased
- Safety MRIs: typically 3–4 scans per year, at approximately $200 per MRI
Please note
None of the above investigations, medications, or infusion-related costs are currently subsidised by Medicare or private health insurance
About The Memory Centre
Our Expertise
Our Philosophy
Our Expertise
At The Memory Centre, our team has years of experience in working with older adults. We are highly skilled in managing complex medical conditions such as Dementia, Alzheimer's and the treatment and management of delirium whilst providing individualised care.
Our Services
Our Philosophy
Our Expertise
We offer a wide range of services, including a:
- Comprehensive Cognitive Assessment,
- Geriatrician Consultations,
- Allied Health,
- Pre and peri operative Assessments,
- Advance Health Directives,
- Driving Simulation,
- Social Support.
Our goal is to provide comprehensive care that meets the unique needs of each individual.
Our Philosophy
Our Philosophy
Our Philosophy
We believe that every person deserves to age with dignity and respect. Our philosophy is centered around empowering older adults to live life on their own terms, with the support they need to thrive.
Here at The Memory Centre we are there every step of the way to help you and your family navigate this next phase of your life.